On November 2, 2025, NFL enthusiasts will be treated to a thrilling matchup as the Kansas City Chiefs take on the Buffalo Bills at Highmark Stadium in Orchard Park, kicking off at 4:25 PM.

The Chiefs, currently second in their division and seventh in the conference, hold a record of 2-2-0, reflecting a .500 winning percentage. They have scored a total of 97 points while conceding 76, resulting in a positive point differential of 21. In contrast, the Bills lead their division and conference with an unblemished 4-0-0 record, boasting a perfect 1.00 winning percentage. They have amassed 133 points and surrendered 90, thus achieving a larger point differential of 43.

In their most recent matchup, the Chiefs emerged victorious over the SF at Levi’s Stadium with a 28-18 win, accumulating 22 first downs and amassing 184 rushing yards and 145 passing yards. On the other hand, the Bills crushed the TEN with a decisive 34-10 victory at home, netting 18 first downs, 74 rushing yards, and an impressive 315 passing yards.

Key performances came from Patrick Mahomes of the Chiefs, who threw for 154 yards and maintained a passer rating of 44.37 despite not scoring any touchdowns. Josh Allen of the Bills, meanwhile, showcased his prowess by throwing for 323 yards, notching 2 touchdowns and an impressive passer rating of 116.1.

As we gear up for this encounter, the spotlight is on the quarterbacks – Patrick Mahomes and Josh Allen – as they prepare to lead their teams in what promises to be a captivating game.

Betting enthusiasts will find interest in the odds set for this game. The Buffalo Bills are favored with a point spread of -2.50 and a moneyline of -143, indicating their strong position. Conversely, the Kansas City Chiefs are listed with a point spread of +2.50 and a moneyline of +121, presenting them as underdogs. The over/under for the game is pegged at 48.70, suggesting expectations of a high-scoring affair. Remember, for more updates on this and other games, keep tabs on betPennsylvaniasports.com.